Cardiorespiratory/sedative effects of a peptide identified in crotalic venom compared to acepromazine and xylazine in horses
نویسندگان
چکیده
ABSTRACT The purpose of this study was to investigate whether intravenous crotalphine produces significant sedation, as well physiological changes, in healthy standing horses. Six mares, aged 8 years and weighing 415kg underwent three different treatments a crossover design: TA (acepromazine: 50μg.kg-1), TC (crotalphine: 0.01μg.kg-1) TX (xylazine: 1000μg.kg-1), intravenously. At various time points over 60 minutes, physiologic variables were recorded: heart rate, respiratory rectal temperature. head height from the ground (HHG) evaluated centimeters. Data analyzed using ANOVA followed by Dunnett’s test or Friedman Dunn’s test, under 5% significance. Heart rate decreased significantly at M5 M10 compared with Mb (28±7, 26±6 40±8 beats/minute-1, respectively; p=0.0004). Respiratory temperature did not differ among groups points. HHG all (p<0.0001). In conclusion, produce reliable durable sedation mares influence cardiorespiratory clinically relevant manner.
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ژورنال
عنوان ژورنال: Arquivo Brasileiro De Medicina Veterinaria E Zootecnia
سال: 2023
ISSN: ['1678-4162', '0102-0935']
DOI: https://doi.org/10.1590/1678-4162-12821